BRD-A15530910_SDZ 21009_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-A15530910_SDZ 21009_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GCH1 GTP cyclohydrolase 1
HBD hemoglobin, delta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SQLE squalene epoxidase
STAR steroidogenic acute regulatory protein
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
FMO2 flavin containing monooxygenase 2 (non-functional)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFI16 interferon, gamma-inducible protein 16
JCHAIN joining chain of multimeric IgA and IgM
LGALS3 lectin, galactoside-binding, soluble, 3
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NXN nucleoredoxin
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
SOX11 SRY (sex determining region Y)-box 11
TFPI2 tissue factor pathway inhibitor 2