BRD-A15530910_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A15530910_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
CAST calpastatin
CD200 CD200 molecule
CD24 CD24 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHMP4A charged multivesicular body protein 4A
CLGN calmegin
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FYB FYN binding protein
GIMAP4 GTPase, IMAP family member 4
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREM1 gremlin 1, DAN family BMP antagonist
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
MCTP1 multiple C2 domains, transmembrane 1
MSMO1 methylsterol monooxygenase 1
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
RCAN1 regulator of calcineurin 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SERINC5 serine incorporator 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TUSC3 tumor suppressor candidate 3
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AUTS2 autism susceptibility candidate 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
FHL1 four and a half LIM domains 1
FMO3 flavin containing monooxygenase 3
FOXD1 forkhead box D1
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IRS1 insulin receptor substrate 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
PRELP proline/arginine-rich end leucine-rich repeat protein
RAD23B RAD23 homolog B (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCF4 transcription factor 4
TFF1 trefoil factor 1
TIMP4 TIMP metallopeptidase inhibitor 4
TUBB6 tubulin, beta 6 class V