BRD-A15530910_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A15530910_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
BHLHE41 basic helix-loop-helix family, member e41
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ELOVL6 ELOVL fatty acid elongase 6
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
LDLR low density lipoprotein receptor
LOX lysyl oxidase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAOA monoamine oxidase A
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PBX3 pre-B-cell leukemia homeobox 3
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
REG1A regenerating islet-derived 1 alpha
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SQLE squalene epoxidase
TNNT1 troponin T type 1 (skeletal, slow)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CETN3 centrin, EF-hand protein, 3
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
IGFBP7 insulin-like growth factor binding protein 7
KRT15 keratin 15, type I
MT1E metallothionein 1E
NRP1 neuropilin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
RAB25 RAB25, member RAS oncogene family
SFN stratifin
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TOR1A torsin family 1, member A (torsin A)
TSPAN7 tetraspanin 7
UFM1 ubiquitin-fold modifier 1
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1