BRD-A15415227_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A15415227_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCDC86 coiled-coil domain containing 86
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FZD6 frizzled class receptor 6
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
MME membrane metallo-endopeptidase
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5DC2 5'-nucleotidase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLIN2 perilipin 2
PPIF peptidylprolyl isomerase F
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TXNDC9 thioredoxin domain containing 9
TXNL4B thioredoxin-like 4B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB18 zinc finger and BTB domain containing 18
ZNF22 zinc finger protein 22

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
AHNAK2 AHNAK nucleoprotein 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CDCA4 cell division cycle associated 4
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNN3 calponin 3, acidic
DAPK1 death-associated protein kinase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUND jun D proto-oncogene
KYNU kynureninase
LTBP2 latent transforming growth factor beta binding protein 2
NPTX2 neuronal pentraxin II
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMP22 peripheral myelin protein 22
PXDN peroxidasin
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAOK3 TAO kinase 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNIP1 TNFAIP3 interacting protein 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM44 tripartite motif containing 44
TYROBP TYRO protein tyrosine kinase binding protein
VSIG4 V-set and immunoglobulin domain containing 4