BRD-A15297126_FLUOCINONIDE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A15297126_FLUOCINONIDE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMDEC1 ADAM-like, decysin 1
AIM1 absent in melanoma 1
C10ORF10 chromosome 10 open reading frame 10
CALML4 calmodulin-like 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD163 CD163 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CLIC5 chloride intracellular channel 5
CLNS1A chloride channel, nucleotide-sensitive, 1A
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
F13A1 coagulation factor XIII, A1 polypeptide
FKBP5 FK506 binding protein 5
FLRT3 fibronectin leucine rich transmembrane protein 3
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFNGR1 interferon gamma receptor 1
IGL immunoglobulin lambda locus
IL13RA1 interleukin 13 receptor, alpha 1
ITGA8 integrin, alpha 8
ITM2A integral membrane protein 2A
JAG1 jagged 1
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MPO myeloperoxidase
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH1 notch 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG10 paternally expressed 10
PER1 period circadian clock 1
PRR15L proline rich 15-like
PTEN phosphatase and tensin homolog
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK1 salt-inducible kinase 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYBU syntabulin (syntaxin-interacting)
THAP11 THAP domain containing 11
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR2 toll-like receptor 2
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARL4C ADP-ribosylation factor-like 4C
CALML5 calmodulin-like 5
CCL2 chemokine (C-C motif) ligand 2
CD79A CD79a molecule, immunoglobulin-associated alpha
CDO1 cysteine dioxygenase type 1
CEMIP cell migration inducing protein, hyaluronan binding
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DERA deoxyribose-phosphate aldolase (putative)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EGR2 early growth response 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADS1 fatty acid desaturase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
KYNU kynureninase
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
NR4A3 nuclear receptor subfamily 4, group A, member 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCP4 Purkinje cell protein 4
PIP prolactin-induced protein
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS21 protease, serine, 21 (testisin)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RTN1 reticulon 1
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2 SERTA domain containing 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TMSB15A thymosin beta 15a
WNT5A wingless-type MMTV integration site family, member 5A
XCL1 chemokine (C motif) ligand 1
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1