BRD-A15297126_FLUOCINONIDE_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A15297126_FLUOCINONIDE_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLEC3B C-type lectin domain family 3, member B
COMP cartilage oligomeric matrix protein
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
FKBP5 FK506 binding protein 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MCL1 myeloid cell leukemia 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MYO1B myosin IB
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NRGN neurogranin (protein kinase C substrate, RC3)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXDN peroxidasin
RBM47 RNA binding motif protein 47
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIRT3 sirtuin 3
SLA Src-like-adaptor
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
TAGLN2 transgelin 2
TCTA T-cell leukemia translocation altered
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADAMDEC1 ADAM-like, decysin 1
ADCY1 adenylate cyclase 1 (brain)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
ASCL1 achaete-scute family bHLH transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB1 defensin, beta 1
DOCK10 dedicator of cytokinesis 10
DUSP4 dual specificity phosphatase 4
EPHB2 EPH receptor B2
ESR1 estrogen receptor 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
HHEX hematopoietically expressed homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
LBH limb bud and heart development
LEF1 lymphoid enhancer-binding factor 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MID1 midline 1
MMP12 matrix metallopeptidase 12
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTS neurotensin
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PNMAL1 paraneoplastic Ma antigen family-like 1
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
STK32B serine/threonine kinase 32B
SYNJ2 synaptojanin 2
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM14B transmembrane protein 14B
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TXNL4B thioredoxin-like 4B