BRD-A15297126_FLUOCINONIDE_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-A15297126_FLUOCINONIDE_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
AQP3 aquaporin 3 (Gill blood group)
C8ORF4 chromosome 8 open reading frame 4
CALML4 calmodulin-like 4
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTX4 deltex 4, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
FASTKD5 FAST kinase domains 5
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
FSTL3 follistatin-like 3 (secreted glycoprotein)
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GPM6B glycoprotein M6B
IRS2 insulin receptor substrate 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLK2 kallikrein-related peptidase 2
LAMB1 laminin, beta 1
LTF lactotransferrin
MAOA monoamine oxidase A
MKNK2 MAP kinase interacting serine/threonine kinase 2
MOCOS molybdenum cofactor sulfurase
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PER1 period circadian clock 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PXN paxillin
RORA RAR-related orphan receptor A
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCG2 secretogranin II
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLPI secretory leukocyte peptidase inhibitor
STAT1 signal transducer and activator of transcription 1, 91kDa
TACC2 transforming, acidic coiled-coil containing protein 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM100 transmembrane protein 100
TMEM255A transmembrane protein 255A
TMEM45A transmembrane protein 45A
TMX4 thioredoxin-related transmembrane protein 4
TREM1 triggering receptor expressed on myeloid cells 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
APP amyloid beta (A4) precursor protein
ARL4C ADP-ribosylation factor-like 4C
ATP8B4 ATPase, class I, type 8B, member 4
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CLU clusterin
COL1A1 collagen, type I, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYBRD1 cytochrome b reductase 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUT deoxyuridine triphosphatase
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLOT1 flotillin 1
FOSL1 FOS-like antigen 1
GREM1 gremlin 1, DAN family BMP antagonist
HAT1 histone acetyltransferase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAT ornithine aminotransferase
PDGFA platelet-derived growth factor alpha polypeptide
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP1GAP RAP1 GTPase activating protein
RBBP8 retinoblastoma binding protein 8
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon