BRD-A15131297_Benazepril hydrochloride_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-A15131297_Benazepril hydrochloride_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAT1 adenosine deaminase, tRNA-specific 1
ADM adrenomedullin
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMT aminomethyltransferase
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BANK1 B-cell scaffold protein with ankyrin repeats 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLDN8 claudin 8
CLIC3 chloride intracellular channel 3
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CYTIP cytohesin 1 interacting protein
DAXX death-domain associated protein
DCN decorin
EFNB3 ephrin-B3
EGFL6 EGF-like-domain, multiple 6
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GJA1 gap junction protein, alpha 1, 43kDa
GSTA1 glutathione S-transferase alpha 1
H2AFV H2A histone family, member V
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOPX HOP homeobox
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
INSM1 insulinoma-associated 1
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MATN2 matrilin 2
MMP2 matrix metallopeptidase 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSMB microseminoprotein, beta-
MT1F metallothionein 1F
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEB nebulin
NELL2 NEL-like 2 (chicken)
NVL nuclear VCP-like
NXN nucleoredoxin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PYCARD PYD and CARD domain containing
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RTN1 reticulon 1
SELENBP1 selenium binding protein 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TCEAL2 transcription elongation factor A (SII)-like 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAP1 TNF receptor-associated protein 1
TRD T cell receptor delta locus
TTN titin
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGR2 anterior gradient 2
AREG amphiregulin
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AXL AXL receptor tyrosine kinase
BIK BCL2-interacting killer (apoptosis-inducing)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CD163 CD163 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2A cyclin-dependent kinase inhibitor 2A
CNOT4 CCR4-NOT transcription complex, subunit 4
COL10A1 collagen, type X, alpha 1
CST3 cystatin C
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV1 ets variant 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
HOXC6 homeobox C6
IL6R interleukin 6 receptor
LTBP3 latent transforming growth factor beta binding protein 3
MAP1B microtubule-associated protein 1B
MRPS16 mitochondrial ribosomal protein S16
MRPS30 mitochondrial ribosomal protein S30
MTDH metadherin
MYLK myosin light chain kinase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY neuropeptide Y
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PRSS2 protease, serine, 2 (trypsin 2)
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SET SET nuclear proto-oncogene
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD2 SMAD family member 2
SRSF7 serine/arginine-rich splicing factor 7
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
THBS4 thrombospondin 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B
ZCCHC24 zinc finger, CCHC domain containing 24