BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCND3 cyclin D3
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL16A1 collagen, type XVI, alpha 1
COMP cartilage oligomeric matrix protein
CREM cAMP responsive element modulator
CST6 cystatin E/M
CTSE cathepsin E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DSE dermatan sulfate epimerase
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
EGR3 early growth response 3
EPYC epiphycan
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FXYD5 FXYD domain containing ion transport regulator 5
GJA1 gap junction protein, alpha 1, 43kDa
GPR88 G protein-coupled receptor 88
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
KLF6 Kruppel-like factor 6
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP2 microfibrillar-associated protein 2
MMP1 matrix metallopeptidase 1
MREG melanoregulin
MTSS1 metastasis suppressor 1
MYO10 myosin X
MYO6 myosin VI
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PON3 paraoxonase 3
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRSS23 protease, serine, 23
RAB31 RAB31, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TCF4 transcription factor 4
TFF1 trefoil factor 1
TMEM30B transmembrane protein 30B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOMM34 translocase of outer mitochondrial membrane 34
TPD52L1 tumor protein D52-like 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AKAP1 A kinase (PRKA) anchor protein 1
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BEX1 brain expressed, X-linked 1
C1ORF115 chromosome 1 open reading frame 115
CD9 CD9 molecule
CDC25B cell division cycle 25B
CPVL carboxypeptidase, vitellogenic-like
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS1 fatty acid desaturase 1
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FPGS folylpolyglutamate synthase
GHR growth hormone receptor
GTSE1 G-2 and S-phase expressed 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
LGALS1 lectin, galactoside-binding, soluble, 1
MOAP1 modulator of apoptosis 1
MPHOSPH9 M-phase phosphoprotein 9
MSMO1 methylsterol monooxygenase 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MZT2A mitotic spindle organizing protein 2A
NCAPD3 non-SMC condensin II complex, subunit D3
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
PCYOX1L prenylcysteine oxidase 1 like
PROSC proline synthetase co-transcribed homolog (bacterial)
RRM1 ribonucleotide reductase M1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
THYN1 thymocyte nuclear protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TRIM68 tripartite motif containing 68
TSPAN8 tetraspanin 8