BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C2 aldo-keto reductase family 1, member C2
ANXA4 annexin A4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLNK B-cell linker
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD8A CD8a molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GYPC glycophorin C (Gerbich blood group)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
HSPG2 heparan sulfate proteoglycan 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
LRP10 low density lipoprotein receptor-related protein 10
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP1 matrix metallopeptidase 1
MYOF myoferlin
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFD platelet derived growth factor D
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLSCR3 phospholipid scramblase 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPM2 tropomyosin 2 (beta)
VGLL4 vestigial-like family member 4
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AMD1 adenosylmethionine decarboxylase 1
ANK2 ankyrin 2, neuronal
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHCR7 7-dehydrocholesterol reductase
DLD dihydrolipoamide dehydrogenase
EBP emopamil binding protein (sterol isomerase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
MCAM melanoma cell adhesion molecule
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MSMO1 methylsterol monooxygenase 1
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
RGS5 regulator of G-protein signaling 5
SAC3D1 SAC3 domain containing 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35F2 solute carrier family 35, member F2
TMEM251 transmembrane protein 251
TUBB tubulin, beta class I
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase