BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_TYKNU_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_TYKNU_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ATXN1 ataxin 1
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC11A C-type lectin domain family 11, member A
CNOT4 CCR4-NOT transcription complex, subunit 4
CST3 cystatin C
CSTA cystatin A (stefin A)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR1 early growth response 1
EGR3 early growth response 3
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
GAGE3 G antigen 3
GPATCH8 G patch domain containing 8
GRB14 growth factor receptor-bound protein 14
GRN granulin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IER3 immediate early response 3
IRF1 interferon regulatory factor 1
ITGA10 integrin, alpha 10
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ODC1 ornithine decarboxylase 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PER1 period circadian clock 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TJP2 tight junction protein 2
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TUBB2A tubulin, beta 2A class IIa
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
YBX3 Y box binding protein 3
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
BAHCC1 BAH domain and coiled-coil containing 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A2 collagen, type I, alpha 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
ELN elastin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP1 fatty acid binding protein 1, liver
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOXF1 forkhead box F1
FOXF2 forkhead box F2
HIST1H1C histone cluster 1, H1c
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LBH limb bud and heart development
MAOA monoamine oxidase A
MBP myelin basic protein
MGLL monoglyceride lipase
MID1 midline 1
MN1 meningioma (disrupted in balanced translocation) 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM4 olfactomedin 4
OXTR oxytocin receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PLLP plasmolipin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSG5 pregnancy specific beta-1-glycoprotein 5
PTPRC protein tyrosine phosphatase, receptor type, C
QPRT quinolinate phosphoribosyltransferase
RAB25 RAB25, member RAS oncogene family
RBM34 RNA binding motif protein 34
RND3 Rho family GTPase 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TIMELESS timeless circadian clock
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TYRP1 tyrosinase-related protein 1
WNT5A wingless-type MMTV integration site family, member 5A