BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA11 annexin A11
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
BZW1 basic leucine zipper and W2 domains 1
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CARD10 caspase recruitment domain family, member 10
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CLEC2B C-type lectin domain family 2, member B
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COL17A1 collagen, type XVII, alpha 1
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
COPA coatomer protein complex, subunit alpha
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYNLT3 dynein, light chain, Tctex-type 3
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FADS3 fatty acid desaturase 3
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
FST follistatin
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GOLT1B golgi transport 1B
GPC1 glypican 1
GPR87 G protein-coupled receptor 87
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
JAG1 jagged 1
JUNB jun B proto-oncogene
JUP junction plakoglobin
KLF5 Kruppel-like factor 5 (intestinal)
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LITAF lipopolysaccharide-induced TNF factor
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
LSR lipolysis stimulated lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP2 latent transforming growth factor beta binding protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLXNA1 plexin A1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PYGB phosphorylase, glycogen; brain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRG1 stimulator of chondrogenesis 1
SDC4 syndecan 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRPX2 sushi-repeat containing protein, X-linked 2
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF1 TNF receptor-associated factor 1
TRIB1 tribbles pseudokinase 1
TSPAN1 tetraspanin 1
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VCL vinculin
VEGFA vascular endothelial growth factor A
WDR1 WD repeat domain 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AHCY adenosylhomocysteinase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
B3GNT1
BLMH bleomycin hydrolase
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CCDC85B coiled-coil domain containing 85B
CD200 CD200 molecule
CFAP20 cilia and flagella associated protein 20
CXCL9 chemokine (C-X-C motif) ligand 9
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DEAF1 DEAF1 transcription factor
DNAAF2 dynein, axonemal, assembly factor 2
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF4B eukaryotic translation initiation factor 4B
ESD esterase D
EXOSC4 exosome component 4
FAM216A family with sequence similarity 216, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOLR1 folate receptor 1 (adult)
GPC3 glypican 3
GTF3A general transcription factor IIIA
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H2BG histone cluster 1, H2bg
HSPB8 heat shock 22kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KAZN kazrin, periplakin interacting protein
LAMP5 lysosomal-associated membrane protein family, member 5
LDOC1 leucine zipper, down-regulated in cancer 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
MACROD1 MACRO domain containing 1
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MLEC malectin
MRPL12 mitochondrial ribosomal protein L12
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUDCD3 NudC domain containing 3
OXA1L oxidase (cytochrome c) assembly 1-like
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PGM1 phosphoglucomutase 1
PLK2 polo-like kinase 2
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
QDPR quinoid dihydropteridine reductase
QPRT quinolinate phosphoribosyltransferase
RET ret proto-oncogene
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
RPL22 ribosomal protein L22
RPP25 ribonuclease P/MRP 25kDa subunit
RRP1B ribosomal RNA processing 1B
SAC3D1 SAC3 domain containing 1
SERBP1 SERPINE1 mRNA binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SORD sorbitol dehydrogenase
SRM spermidine synthase
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
THAP11 THAP domain containing 11
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM97 transmembrane protein 97
WDR3 WD repeat domain 3
ZC3H13 zinc finger CCCH-type containing 13