BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SW480_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
COL6A1 collagen, type VI, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DST dystonin
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FGG fibrinogen gamma chain
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GPC1 glypican 1
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIN2 Ras and Rab interactor 2
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UPP1 uridine phosphorylase 1
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ANXA6 annexin A6
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL14 chemokine (C-X-C motif) ligand 14
DAPK1 death-associated protein kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELF5 E74-like factor 5 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FUCA1 fucosidase, alpha-L- 1, tissue
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPX3 glutathione peroxidase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HMGN5 high mobility group nucleosome binding domain 5
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIAA0101 KIAA0101
MACF1 microtubule-actin crosslinking factor 1
MDM1 Mdm1 nuclear protein homolog (mouse)
MFAP4 microfibrillar-associated protein 4
NPY1R neuropeptide Y receptor Y1
PEG3 paternally expressed 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RPIA ribose 5-phosphate isomerase A
S100A7 S100 calcium binding protein A7
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC46A3 solute carrier family 46, member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX10 sorting nexin 10
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM45A transmembrane protein 45A
TRIL TLR4 interactor with leucine-rich repeats
TYRP1 tyrosinase-related protein 1