BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL10 B-cell CLL/lymphoma 10
BIRC3 baculoviral IAP repeat containing 3
CALB1 calbindin 1, 28kDa
CARD10 caspase recruitment domain family, member 10
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CEP170 centrosomal protein 170kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CPM carboxypeptidase M
CRYAB crystallin, alpha B
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMXL2 Dmx-like 2
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EVI2B ecotropic viral integration site 2B
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA6 GATA binding protein 6
GPC1 glypican 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MYL12B myosin, light chain 12B, regulatory
NAV3 neuron navigator 3
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKP2 plakophilin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RBBP8 retinoblastoma binding protein 8
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RNF19B ring finger protein 19B
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STK26 serine/threonine protein kinase 26
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMC5 transmembrane channel-like 5
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CCND2 cyclin D2
CH25H cholesterol 25-hydroxylase
CLCA1 chloride channel accessory 1
COA3 cytochrome c oxidase assembly factor 3
COMT catechol-O-methyltransferase
CYB5A cytochrome b5 type A (microsomal)
DEFA5 defensin, alpha 5, Paneth cell-specific
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
NEBL nebulette
NHP2 NHP2 ribonucleoprotein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NRN1 neuritin 1
OLFML3 olfactomedin-like 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PRKD3 protein kinase D3
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRG protein tyrosine phosphatase, receptor type, G
QPRT quinolinate phosphoribosyltransferase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF7 serine/arginine-rich splicing factor 7
TMEM97 transmembrane protein 97
TP53 tumor protein p53
TSPYL5 TSPY-like 5