BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNU1040_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNU1040_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
COL10A1 collagen, type X, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSB cathepsin B
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
FAP fibroblast activation protein, alpha
FBP1 fructose-1,6-bisphosphatase 1
G0S2 G0/G1 switch 2
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LY96 lymphocyte antigen 96
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MGAM maltase-glucoamylase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP3 matrix metallopeptidase 3
MSLN mesothelin
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OSBPL1A oxysterol binding protein-like 1A
OSBPL8 oxysterol binding protein-like 8
PDLIM4 PDZ and LIM domain 4
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PXDN peroxidasin
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RIPK2 receptor-interacting serine-threonine kinase 2
RRAGD Ras-related GTP binding D
S100A12 S100 calcium binding protein A12
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SELE selectin E
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQRDL sulfide quinone reductase-like (yeast)
SRI sorcin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
AURKA aurora kinase A
B3GNT1
BEX1 brain expressed, X-linked 1
C7 complement component 7
CALD1 caldesmon 1
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CES1 carboxylesterase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EHBP1 EH domain binding protein 1
EMX2 empty spiracles homeobox 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOLC1 nucleolar and coiled-body phosphoprotein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PNN pinin, desmosome associated protein
PSIP1 PC4 and SFRS1 interacting protein 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAD51C RAD51 paralog C
RAE1 ribonucleic acid export 1
RBP1 retinol binding protein 1, cellular
RUNX3 runt-related transcription factor 3
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TSPYL1 TSPY-like 1
TWIST1 twist family bHLH transcription factor 1
UPK1B uroplakin 1B
VWF von Willebrand factor
YME1L1 YME1-like 1 ATPase