BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

233 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
AMDHD2 amidohydrolase domain containing 2
ANXA5 annexin A5
AQP9 aquaporin 9
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
C5AR1 complement component 5a receptor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CPB1 carboxypeptidase B1 (tissue)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGA1 high mobility group AT-hook 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA1598
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LSR lipolysis stimulated lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MMP1 matrix metallopeptidase 1
MMP19 matrix metallopeptidase 19
MSLN mesothelin
MT1M metallothionein 1M
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAB7A RAB7A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP4 retinol binding protein 4, plasma
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SDCBP syndecan binding protein (syntenin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOAT1 sterol O-acyltransferase 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TOMM34 translocase of outer mitochondrial membrane 34
TP53BP2 tumor protein p53 binding protein 2
TRAF1 TNF receptor-associated factor 1
TRIO trio Rho guanine nucleotide exchange factor
UBE2E3 ubiquitin-conjugating enzyme E2E 3
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BLNK B-cell linker
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTN3A3 butyrophilin, subfamily 3, member A3
CA12 carbonic anhydrase XII
CBR4 carbonyl reductase 4
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLCA2 chloride channel accessory 2
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DMD dystrophin
ERLIN2 ER lipid raft associated 2
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GJA1 gap junction protein, alpha 1, 43kDa
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HLTF helicase-like transcription factor
HOXA10 homeobox A10
HOXB7 homeobox B7
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGKC immunoglobulin kappa constant
IVNS1ABP influenza virus NS1A binding protein
KIF20A kinesin family member 20A
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
LAMA4 laminin, alpha 4
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MLEC malectin
MPPED2 metallophosphoesterase domain containing 2
MSRB2 methionine sulfoxide reductase B2
MYLIP myosin regulatory light chain interacting protein
NANOG Nanog homeobox
NKG7 natural killer cell granule protein 7
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PBX1 pre-B-cell leukemia homeobox 1
PCYOX1 prenylcysteine oxidase 1
PEBP1 phosphatidylethanolamine binding protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PNISR PNN-interacting serine/arginine-rich protein
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PVALB parvalbumin
PYCARD PYD and CARD domain containing
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCAN2 regulator of calcineurin 2
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SEPW1 selenoprotein W, 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOX4 SRY (sex determining region Y)-box 4
SYNM synemin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIL TLR4 interactor with leucine-rich repeats
TRIM22 tripartite motif containing 22
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV3 vav 3 guanine nucleotide exchange factor
VSNL1 visinin-like 1