BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
AREG amphiregulin
ASPN asporin
C3ORF52 chromosome 3 open reading frame 52
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHMP2B charged multivesicular body protein 2B
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FAM46A family with sequence similarity 46, member A
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD5 potassium channel tetramerization domain containing 5
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LPXN leupaxin
MAN1A1 mannosidase, alpha, class 1A, member 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MSX1 msh homeobox 1
MTSS1 metastasis suppressor 1
MYO10 myosin X
MYO1B myosin IB
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB31 RAB31, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RHOQ ras homolog family member Q
S100A2 S100 calcium binding protein A2
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SIK3 SIK family kinase 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TRIB1 tribbles pseudokinase 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG6 adhesion G protein-coupled receptor G6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
B3GNT1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
C14ORF159 chromosome 14 open reading frame 159
CAT catalase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FAM69A family with sequence similarity 69, member A
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
HADH hydroxyacyl-CoA dehydrogenase
HMG20B high mobility group 20B
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
LIG1 ligase I, DNA, ATP-dependent
LYPD1 LY6/PLAUR domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MID1 midline 1
MN1 meningioma (disrupted in balanced translocation) 1
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PGRMC2 progesterone receptor membrane component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
PODXL podocalyxin-like
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRR7 proline rich 7 (synaptic)
PSIP1 PC4 and SFRS1 interacting protein 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase