BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
BZW1 basic leucine zipper and W2 domains 1
C1ORF106 chromosome 1 open reading frame 106
C3ORF52 chromosome 3 open reading frame 52
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CTSE cathepsin E
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EHD1 EH-domain containing 1
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB6 integrin, beta 6
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSMR oncostatin M receptor
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RBMS1 RNA binding motif, single stranded interacting protein 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF19B ring finger protein 19B
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SELE selectin E
SERTAD2 SERTA domain containing 2
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STK17A serine/threonine kinase 17a
SYNJ2 synaptojanin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TMPRSS4 transmembrane protease, serine 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFC vascular endothelial growth factor C
WTAP Wilms tumor 1 associated protein
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREBL2 cAMP responsive element binding protein-like 2
CXCL13 chemokine (C-X-C motif) ligand 13
DSP desmoplakin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100272216 uncharacterized LOC100272216
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
MID1 midline 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NUPR1 nuclear protein, transcriptional regulator, 1
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RBM47 RNA binding motif protein 47
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RNF43 ring finger protein 43
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SYBU syntabulin (syntaxin-interacting)
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor
XCL1 chemokine (C motif) ligand 1