BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP13 A kinase (PRKA) anchor protein 13
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDND1 claudin domain containing 1
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CTH cystathionine gamma-lyase
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO3 forkhead box O3
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG20 interferon stimulated exonuclease gene 20kDa
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MDK midkine (neurite growth-promoting factor 2)
MFAP2 microfibrillar-associated protein 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PSEN1 presenilin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SELE selectin E
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TP53BP2 tumor protein p53 binding protein 2
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WDR45 WD repeat domain 45
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
B3GNT1
BCLAF1 BCL2-associated transcription factor 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CLU clusterin
DICER1 dicer 1, ribonuclease type III
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD3 EH-domain containing 3
EIF5 eukaryotic translation initiation factor 5
FAM98A family with sequence similarity 98, member A
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FASN fatty acid synthase
GATA2 GATA binding protein 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA10 homeobox A10
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGLL1 immunoglobulin lambda-like polypeptide 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF20A kinesin family member 20A
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MSMO1 methylsterol monooxygenase 1
MTCL1 microtubule crosslinking factor 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRN1 neuritin 1
OLFM1 olfactomedin 1
PNN pinin, desmosome associated protein
PRUNE2 prune homolog 2 (Drosophila)
QDPR quinoid dihydropteridine reductase
RANBP6 RAN binding protein 6
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SFPQ splicing factor proline/glutamine-rich
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
SYBU syntabulin (syntaxin-interacting)
TBC1D4 TBC1 domain family, member 4
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)