BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NOMO1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

290 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NOMO1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ANXA5 annexin A5
AQP9 aquaporin 9
AREG amphiregulin
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
AZIN1 antizyme inhibitor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
C5AR1 complement component 5a receptor 1
C6ORF62 chromosome 6 open reading frame 62
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CCRL2 chemokine (C-C motif) receptor-like 2
CD52 CD52 molecule
CD86 CD86 molecule
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC5A C-type lectin domain family 5, member A
COL10A1 collagen, type X, alpha 1
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FCMR Fc fragment of IgM receptor
FERMT2 fermitin family member 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GOLT1B golgi transport 1B
GPC1 glypican 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ITGAV integrin, alpha V
JAG1 jagged 1
JUNB jun B proto-oncogene
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LITAF lipopolysaccharide-induced TNF factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP2 microfibrillar-associated protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
NCF2 neutrophil cytosolic factor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PID1 phosphotyrosine interaction domain containing 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PLIN2 perilipin 2
PLXNA1 plexin A1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOC ras homolog family member C
RYBP RING1 and YY1 binding protein
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
VCAN versican
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AK2 adenylate kinase 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASRGL1 asparaginase like 1
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BLVRA biliverdin reductase A
BST2 bone marrow stromal cell antigen 2
C20ORF27 chromosome 20 open reading frame 27
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CCNA2 cyclin A2
CCND3 cyclin D3
CD320 CD320 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CLEC11A C-type lectin domain family 11, member A
COG4 component of oligomeric golgi complex 4
CSTA cystatin A (stefin A)
CTSC cathepsin C
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYTL1 cytokine-like 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DUT deoxyuridine triphosphatase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM111A family with sequence similarity 111, member A
FAM216A family with sequence similarity 216, member A
FAM46A family with sequence similarity 46, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GOLGA8H golgin A8 family, member H
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5D lysine (K)-specific demethylase 5D
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LIG1 ligase I, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
LY75 lymphocyte antigen 75
LYZ lysozyme
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
METTL7A methyltransferase like 7A
MFSD1 major facilitator superfamily domain containing 1
MGLL monoglyceride lipase
MGST2 microsomal glutathione S-transferase 2
MNDA myeloid cell nuclear differentiation antigen
MRPL12 mitochondrial ribosomal protein L12
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYCBP MYC binding protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP210 nucleoporin 210kDa
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PPA1 pyrophosphatase (inorganic) 1
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
QDPR quinoid dihydropteridine reductase
RASA4 RAS p21 protein activator 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPA1 replication protein A1, 70kDa
RPS27L ribosomal protein S27-like
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM106C transmembrane protein 106C
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNG uracil-DNA glycosylase
VAMP8 vesicle-associated membrane protein 8