BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NCIH508_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

211 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NCIH508_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARL14 ADP-ribosylation factor-like 14
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C16ORF45 chromosome 16 open reading frame 45
CAB39 calcium binding protein 39
CAPN2 calpain 2, (m/II) large subunit
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CERK ceramide kinase
CLIC4 chloride intracellular channel 4
CLTB clathrin, light chain B
COL17A1 collagen, type XVII, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSG3 desmoglein 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPHA2 EPH receptor A2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB6 integrin, beta 6
JAG1 jagged 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LMNA lamin A/C
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1X metallothionein 1X
MT2A metallothionein 2A
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G10 phospholipase A2, group X
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPARD peroxisome proliferator-activated receptor delta
PRNP prion protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAP25 synaptosomal-associated protein, 25kDa
SOWAHC sosondowah ankyrin repeat domain family member C
SPRR1B small proline-rich protein 1B
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
UBE2A ubiquitin-conjugating enzyme E2A
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CDK4 cyclin-dependent kinase 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBB cytochrome b-245, beta polypeptide
ERLIN2 ER lipid raft associated 2
HNMT histamine N-methyltransferase
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IRF8 interferon regulatory factor 8
KCTD12 potassium channel tetramerization domain containing 12
LEPR leptin receptor
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCM3 minichromosome maintenance complex component 3
MID1 midline 1
MLEC malectin
MME membrane metallo-endopeptidase
MRPL12 mitochondrial ribosomal protein L12
MRPL19 mitochondrial ribosomal protein L19
MYB v-myb avian myeloblastosis viral oncogene homolog
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NOTCH1 notch 1
OLFML3 olfactomedin-like 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PLA1A phospholipase A1 member A
PLBD1 phospholipase B domain containing 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QDPR quinoid dihydropteridine reductase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM47 RNA binding motif protein 47
REPIN1 replication initiator 1
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
TBL1X transducin (beta)-like 1X-linked
TMEM97 transmembrane protein 97
TP53 tumor protein p53
UNG uracil-DNA glycosylase
ZC3H13 zinc finger CCCH-type containing 13