BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMPD3 adenosine monophosphate deaminase 3
ANO1 anoctamin 1, calcium activated chloride channel
ANXA5 annexin A5
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
BCL2A1 BCL2-related protein A1
BGN biglycan
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C8ORF4 chromosome 8 open reading frame 4
CAST calpastatin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CTSB cathepsin B
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DPP4 dipeptidyl-peptidase 4
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
EHD1 EH-domain containing 1
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FLNA filamin A, alpha
G0S2 G0/G1 switch 2
GLS glutaminase
GPM6A glycoprotein M6A
GPR137B G protein-coupled receptor 137B
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
IL6 interleukin 6
INHBA inhibin, beta A
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYO1D myosin ID
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRKCD protein kinase C, delta
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRE protein tyrosine phosphatase, receptor type, E
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RNF167 ring finger protein 167
RNF19B ring finger protein 19B
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
STK39 serine threonine kinase 39
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TLR2 toll-like receptor 2
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TREM1 triggering receptor expressed on myeloid cells 1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VNN1 vanin 1
WSB1 WD repeat and SOCS box containing 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CNN3 calponin 3, acidic
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FKBP11 FK506 binding protein 11, 19 kDa
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSDL2 hydroxysteroid dehydrogenase like 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
MEIS2 Meis homeobox 2
MID1 midline 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOLC1 nucleolar and coiled-body phosphoprotein 1
OLFML3 olfactomedin-like 3
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
PARP2 poly (ADP-ribose) polymerase 2
PBX3 pre-B-cell leukemia homeobox 3
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1D2 secretoglobin, family 1D, member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPAG16 sperm associated antigen 16
STAT1 signal transducer and activator of transcription 1, 91kDa
TCTN1 tectonic family member 1
TPM1 tropomyosin 1 (alpha)
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WT1 Wilms tumor 1