BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AMPD3 adenosine monophosphate deaminase 3
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA1 cyclin A1
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK17 cyclin-dependent kinase 17
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
FAM171A1 family with sequence similarity 171, member A1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INHBA inhibin, beta A
JAG1 jagged 1
JUNB jun B proto-oncogene
KYNU kynureninase
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LIMS1 LIM and senescent cell antigen-like domains 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MYO10 myosin X
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PNP purine nucleoside phosphorylase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRE protein tyrosine phosphatase, receptor type, E
RGCC regulator of cell cycle
RIPK2 receptor-interacting serine-threonine kinase 2
RPS11 ribosomal protein S11
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SREBF1 sterol regulatory element binding transcription factor 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
STK38L serine/threonine kinase 38 like
SUSD6 sushi domain containing 6
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TOP1 topoisomerase (DNA) I
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TRIB1 tribbles pseudokinase 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
USP6NL USP6 N-terminal like
VGLL4 vestigial-like family member 4
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AP2M1 adaptor-related protein complex 2, mu 1 subunit
BEX1 brain expressed, X-linked 1
C7 complement component 7
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALD1 caldesmon 1
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL6A3 collagen, type VI, alpha 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FDXR ferredoxin reductase
FEN1 flap structure-specific endonuclease 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FSTL1 follistatin-like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALE UDP-galactose-4-epimerase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MRPS7 mitochondrial ribosomal protein S7
MSH2 mutS homolog 2
NFIB nuclear factor I/B
NUP85 nucleoporin 85kDa
OLFM1 olfactomedin 1
PALLD palladin, cytoskeletal associated protein
PARP2 poly (ADP-ribose) polymerase 2
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRC1 protein regulator of cytokinesis 1
PSPH phosphoserine phosphatase
REEP1 receptor accessory protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC1 syndecan 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SQLE squalene epoxidase
SRSF7 serine/arginine-rich splicing factor 7
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN transgelin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TRBC1 T cell receptor beta constant 1
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UNG uracil-DNA glycosylase
VDAC3 voltage-dependent anion channel 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein