BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

290 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRE5 adhesion G protein-coupled receptor E5
AGO2 argonaute RISC catalytic component 2
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
CAPN2 calpain 2, (m/II) large subunit
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHMP2B charged multivesicular body protein 2B
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLC Charcot-Leyden crystal galectin
CLDND1 claudin domain containing 1
COTL1 coactosin-like F-actin binding protein 1
CREM cAMP responsive element modulator
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST6 cystatin E/M
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP3 epithelial membrane protein 3
EPHA2 EPH receptor A2
EREG epiregulin
ERO1L ERO1-like (S. cerevisiae)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FBN2 fibrillin 2
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL32 interleukin 32
IL4R interleukin 4 receptor
IL6 interleukin 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLK6 kallikrein-related peptidase 6
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LITAF lipopolysaccharide-induced TNF factor
LRP10 low density lipoprotein receptor-related protein 10
LRRC16A leucine rich repeat containing 16A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTHLH parathyroid hormone-like hormone
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOMM34 translocase of outer mitochondrial membrane 34
TP53BP2 tumor protein p53 binding protein 2
TRAF1 TNF receptor-associated factor 1
TRIB1 tribbles pseudokinase 1
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIM vimentin
WARS tryptophanyl-tRNA synthetase
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZYX zyxin

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADIRF adipogenesis regulatory factor
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASTN2 astrotactin 2
ATF5 activating transcription factor 5
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AURKA aurora kinase A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BRD8 bromodomain containing 8
C14ORF132 chromosome 14 open reading frame 132
C1QA complement component 1, q subcomponent, A chain
CCL19 chemokine (C-C motif) ligand 19
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1A carnitine palmitoyltransferase 1A (liver)
CSAD cysteine sulfinic acid decarboxylase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EHD3 EH-domain containing 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FCGBP Fc fragment of IgG binding protein
GLUL glutamate-ammonia ligase
HLF hepatic leukemia factor
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
LEPR leptin receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MSH6 mutS homolog 6
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP107 nucleoporin 107kDa
OLFM1 olfactomedin 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXDN peroxidasin
RAD51C RAD51 paralog C
RGS5 regulator of G-protein signaling 5
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
TCF4 transcription factor 4
THYN1 thymocyte nuclear protein 1
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VWF von Willebrand factor