BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CCNG2 cyclin G2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CHGB chromogranin B
CHN2 chimerin 2
CLDN3 claudin 3
CST1 cystatin SN
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPAS1 endothelial PAS domain protein 1
FGF9 fibroblast growth factor 9
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2R insulin-like growth factor 2 receptor
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAMA3 laminin, alpha 3
LRP10 low density lipoprotein receptor-related protein 10
MSMB microseminoprotein, beta-
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYO1E myosin IE
NEU1 sialidase 1 (lysosomal sialidase)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL10 oxysterol binding protein-like 10
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRSS23 protease, serine, 23
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGC Ras-related GTP binding C
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP1 secreted frizzled-related protein 1
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADK adenosine kinase
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AURKA aurora kinase A
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHEK2 checkpoint kinase 2
CPE carboxypeptidase E
DCN decorin
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FANCI Fanconi anemia, complementation group I
GEMIN2 gem (nuclear organelle) associated protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LOXL1 lysyl oxidase-like 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MDM1 Mdm1 nuclear protein homolog (mouse)
MT1F metallothionein 1F
MT1M metallothionein 1M
NKTR natural killer cell triggering receptor
NUP85 nucleoporin 85kDa
NUP93 nucleoporin 93kDa
NUTF2 nuclear transport factor 2
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PKN2 protein kinase N2
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNN pinin, desmosome associated protein
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKD3 protein kinase D3
PTX3 pentraxin 3, long
RHOBTB3 Rho-related BTB domain containing 3
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
SESN1 sestrin 1
SF1 splicing factor 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SPDL1 spindle apparatus coiled-coil protein 1
TAGLN transgelin
TFAM transcription factor A, mitochondrial
TRA2B transformer 2 beta homolog (Drosophila)
UBE2C ubiquitin-conjugating enzyme E2C