BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BCL10 B-cell CLL/lymphoma 10
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CTSL cathepsin L
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KCTD9 potassium channel tetramerization domain containing 9
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LOX lysyl oxidase
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCD protein kinase C, delta
PTX3 pentraxin 3, long
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELE selectin E
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPHK1 sphingosine kinase 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AKAP7 A kinase (PRKA) anchor protein 7
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BRCA1 breast cancer 1, early onset
C14ORF132 chromosome 14 open reading frame 132
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
COA3 cytochrome c oxidase assembly factor 3
CRYAB crystallin, alpha B
DIXDC1 DIX domain containing 1
DMD dystrophin
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP1 fatty acid binding protein 1, liver
FBXO9 F-box protein 9
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8H golgin A8 family, member H
HRSP12 heat-responsive protein 12
HSPB8 heat shock 22kDa protein 8
ITM2A integral membrane protein 2A
LEPR leptin receptor
MAGEA3 melanoma antigen family A3
MID1 midline 1
OLFM4 olfactomedin 4
PRKCB protein kinase C, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
QDPR quinoid dihydropteridine reductase
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
THAP11 THAP domain containing 11
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)