BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ANPEP alanyl (membrane) aminopeptidase
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CD24 CD24 molecule
CD53 CD53 molecule
CD9 CD9 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DSG3 desmoglein 3
EGFR epidermal growth factor receptor
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FERMT2 fermitin family member 2
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
HSPA13 heat shock protein 70kDa family, member 13
HTRA1 HtrA serine peptidase 1
ITGAV integrin, alpha V
KIAA0125 KIAA0125
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMO4 LIM domain only 4
LRRC15 leucine rich repeat containing 15
LTBP1 latent transforming growth factor beta binding protein 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
NARFL nuclear prelamin A recognition factor-like
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PPAP2B phosphatidic acid phosphatase type 2B
PRKX protein kinase, X-linked
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SFN stratifin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL1 adhesion G protein-coupled receptor L1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML4 calmodulin-like 4
CASP6 caspase 6, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDCA4 cell division cycle associated 4
CYBA cytochrome b-245, alpha polypeptide
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GPX4 glutathione peroxidase 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IRS2 insulin receptor substrate 2
ISYNA1 inositol-3-phosphate synthase 1
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCAM melanoma cell adhesion molecule
MYH11 myosin, heavy chain 11, smooth muscle
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAT ornithine aminotransferase
PLCB4 phospholipase C, beta 4
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNH1 ribonuclease/angiogenin inhibitor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
THSD7A thrombospondin, type I, domain containing 7A
TNNT1 troponin T type 1 (skeletal, slow)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TPPP3 tubulin polymerization-promoting protein family member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZMYND8 zinc finger, MYND-type containing 8