BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AKAP13 A kinase (PRKA) anchor protein 13
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3ORF52 chromosome 3 open reading frame 52
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
COL6A1 collagen, type VI, alpha 1
CORO1C coronin, actin binding protein, 1C
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK1E casein kinase 1, epsilon
CTSB cathepsin B
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EHD1 EH-domain containing 1
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KDM7A lysine (K)-specific demethylase 7A
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRE protein tyrosine phosphatase, receptor type, E
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERTAD2 SERTA domain containing 2
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPD surfactant protein D
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC43A3 solute carrier family 43, member 3
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TAC1 tachykinin, precursor 1
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
B3GNT1
C3 complement component 3
CFH complement factor H
CLU clusterin
COL5A1 collagen, type V, alpha 1
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FBLN1 fibulin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HMGB1 high mobility group box 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
LEPR leptin receptor
LUM lumican
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MSH2 mutS homolog 2
MUC16 mucin 16, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NUP107 nucleoporin 107kDa
OLFML3 olfactomedin-like 3
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKP4 plakophilin 4
PLK1 polo-like kinase 1
PSCA prostate stem cell antigen
PSIP1 PC4 and SFRS1 interacting protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPINK1 serine peptidase inhibitor, Kazal type 1
SYBU syntabulin (syntaxin-interacting)
TMEM97 transmembrane protein 97
TPD52 tumor protein D52
TSPAN12 tetraspanin 12
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UNG uracil-DNA glycosylase
VAV3 vav 3 guanine nucleotide exchange factor
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1