BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
CAPG capping protein (actin filament), gelsolin-like
CCND1 cyclin D1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD46 CD46 molecule, complement regulatory protein
CDCP1 CUB domain containing protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL13A1 collagen, type XIII, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DUSP6 dual specificity phosphatase 6
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSPT2 G1 to S phase transition 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LIPG lipase, endothelial
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAX8 paired box 8
PLAU plasminogen activator, urokinase
PLSCR1 phospholipid scramblase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RSAD2 radical S-adenosyl methionine domain containing 2
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
C6ORF48 chromosome 6 open reading frame 48
CCNB2 cyclin B2
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
DAAM1 dishevelled associated activator of morphogenesis 1
DSP desmoplakin
EDN1 endothelin 1
EIF4A3 eukaryotic translation initiation factor 4A3
ELN elastin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
F13A1 coagulation factor XIII, A1 polypeptide
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD2 3-hydroxyacyl-CoA dehydratase 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KLF10 Kruppel-like factor 10
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
LBH limb bud and heart development
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
NREP neuronal regeneration related protein
OLFML3 olfactomedin-like 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA5 protein disulfide isomerase family A, member 5
PRSS23 protease, serine, 23
RHOB ras homolog family member B
SKP1 S-phase kinase-associated protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMS spermine synthase
TRAK2 trafficking protein, kinesin binding 2
TUBB2A tubulin, beta 2A class IIa
XBP1 X-box binding protein 1