BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_COV644_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_COV644_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP13A3 ATPase type 13A3
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CSNK1E casein kinase 1, epsilon
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AE histone cluster 1, H2ae
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HOMER1 homer scaffolding protein 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IER3 immediate early response 3
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYO10 myosin X
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OXSR1 oxidative stress responsive 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PDHX pyruvate dehydrogenase complex, component X
PDLIM5 PDZ and LIM domain 5
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
PPARD peroxisome proliferator-activated receptor delta
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFRC transferrin receptor
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPM4 tropomyosin 4
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
C14ORF132 chromosome 14 open reading frame 132
C3ORF14 chromosome 3 open reading frame 14
CD200 CD200 molecule
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHN1 chimerin 1
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC3B C-type lectin domain family 3, member B
CLIC2 chloride intracellular channel 2
COG2 component of oligomeric golgi complex 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DERA deoxyribose-phosphate aldolase (putative)
DHCR24 24-dehydrocholesterol reductase
DPT dermatopontin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN2 ER lipid raft associated 2
FCGBP Fc fragment of IgG binding protein
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GLB1L2 galactosidase, beta 1-like 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GSE1 Gse1 coiled-coil protein
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
L1TD1 LINE-1 type transposase domain containing 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MXRA5 matrix-remodelling associated 5
NCOA2 nuclear receptor coactivator 2
NDN necdin, melanoma antigen (MAGE) family member
NPC2 Niemann-Pick disease, type C2
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
NVL nuclear VCP-like
OLFML3 olfactomedin-like 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN1 regulator of calcineurin 1
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SALL2 spalt-like transcription factor 2
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SYT1 synaptotagmin I
TMEM106C transmembrane protein 106C
TMEM97 transmembrane protein 97
TPPP3 tubulin polymerization-promoting protein family member 3
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VWA5A von Willebrand factor A domain containing 5A
WWOX WW domain containing oxidoreductase