BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_CL34_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABI1 abl-interactor 1
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AXL AXL receptor tyrosine kinase
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BZW1 basic leucine zipper and W2 domains 1
CAB39 calcium binding protein 39
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CREB5 cAMP responsive element binding protein 5
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMTF1 cyclin D binding myb-like transcription factor 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EHD1 EH-domain containing 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GMFB glia maturation factor, beta
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
IL1RL1 interleukin 1 receptor-like 1
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB6 integrin, beta 6
JAG1 jagged 1
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0040 KIAA0040
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LITAF lipopolysaccharide-induced TNF factor
LMNA lamin A/C
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MSN moesin
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLEC plectin
PLIN3 perilipin 3
PMEPA1 prostate transmembrane protein, androgen induced 1
POSTN periostin, osteoblast specific factor
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRNP prion protein
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPHK1 sphingosine kinase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TES testin LIM domain protein
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TSPAN1 tetraspanin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHEK1 checkpoint kinase 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COPS7A COP9 signalosome subunit 7A
CP ceruloplasmin (ferroxidase)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DENND1B DENN/MADD domain containing 1B
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FHOD3 formin homology 2 domain containing 3
GGCT gamma-glutamylcyclotransferase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
KDM5D lysine (K)-specific demethylase 5D
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MCM3 minichromosome maintenance complex component 3
MDM1 Mdm1 nuclear protein homolog (mouse)
MLEC malectin
MUC16 mucin 16, cell surface associated
NARF nuclear prelamin A recognition factor
NRCAM neuronal cell adhesion molecule
PLBD1 phospholipase B domain containing 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RAB15 RAB15, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TGFBI transforming growth factor, beta-induced, 68kDa
TOX thymocyte selection-associated high mobility group box
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TYRP1 tyrosinase-related protein 1
WT1 Wilms tumor 1