BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

270 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF52 chromosome 3 open reading frame 52
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLCA4 chloride channel accessory 4
CLDN8 claudin 8
CLDND1 claudin domain containing 1
CRIP1 cysteine-rich protein 1 (intestinal)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HOMER3 homer scaffolding protein 3
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IFT57 intraflagellar transport 57
IL1R2 interleukin 1 receptor, type II
INPP1 inositol polyphosphate-1-phosphatase
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LPXN leupaxin
MAB21L1 mab-21-like 1 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAX MYC associated factor X
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMU neuromedin U
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OGFRL1 opioid growth factor receptor-like 1
PDLIM4 PDZ and LIM domain 4
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPIF peptidylprolyl isomerase F
PPL periplakin
PRKCD protein kinase C, delta
PRSS3 protease, serine, 3
PTHLH parathyroid hormone-like hormone
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
PTX3 pentraxin 3, long
RAB27A RAB27A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RALGDS ral guanine nucleotide dissociation stimulator
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF19B ring finger protein 19B
RTN2 reticulon 2
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERINC1 serine incorporator 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SYNE2 spectrin repeat containing, nuclear envelope 2
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
WBP5 WW domain binding protein 5
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6

decreased expression

Symbol Name
AFP alpha-fetoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOA2 apolipoprotein A-II
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATRAID all-trans retinoic acid-induced differentiation factor
B3GNT1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCND2 cyclin D2
CLIC3 chloride intracellular channel 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCTD dCMP deaminase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB2 erb-b2 receptor tyrosine kinase 2
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FLRT2 fibronectin leucine rich transmembrane protein 2
G6PC3 glucose 6 phosphatase, catalytic, 3
GPC3 glypican 3
HEBP1 heme binding protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KDM5D lysine (K)-specific demethylase 5D
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MSMB microseminoprotein, beta-
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NGRN neugrin, neurite outgrowth associated
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFML3 olfactomedin-like 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDE8B phosphodiesterase 8B
PLSCR3 phospholipid scramblase 3
PON2 paraoxonase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
QPRT quinolinate phosphoribosyltransferase
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIDT2 SID1 transmembrane family, member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS1 sorbin and SH3 domain containing 1
TAGLN transgelin
TARBP1 TAR (HIV-1) RNA binding protein 1
TCTA T-cell leukemia translocation altered
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
WFS1 Wolfram syndrome 1 (wolframin)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZMAT3 zinc finger, matrin-type 3