BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

139 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADORA2B adenosine A2b receptor
AREG amphiregulin
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EPHB2 EPH receptor B2
EZR ezrin
FBLN1 fibulin 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
INPP1 inositol polyphosphate-1-phosphatase
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK6 kallikrein-related peptidase 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIMA1 LIM domain and actin binding 1
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
PF4 platelet factor 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RALGDS ral guanine nucleotide dissociation stimulator
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SPON1 spondin 1, extracellular matrix protein
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TCF4 transcription factor 4
TESC tescalcin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACSL3 acyl-CoA synthetase long-chain family member 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CAST calpastatin
CCDC92 coiled-coil domain containing 92
CETN2 centrin, EF-hand protein, 2
CHMP4A charged multivesicular body protein 4A
COBL cordon-bleu WH2 repeat protein
CPNE3 copine III
CSRP1 cysteine and glycine-rich protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS1 dehydrogenase/reductase (SDR family) member 1
FABP4 fatty acid binding protein 4, adipocyte
FAM111A family with sequence similarity 111, member A
FBP1 fructose-1,6-bisphosphatase 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ITGB1BP1 integrin beta 1 binding protein 1
KRT7 keratin 7, type II
LPIN1 lipin 1
LPL lipoprotein lipase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MINA MYC induced nuclear antigen
MT1F metallothionein 1F
NAV2 neuron navigator 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCYOX1 prenylcysteine oxidase 1
PDZRN3 PDZ domain containing ring finger 3
PHYH phytanoyl-CoA 2-hydroxylase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLS3 plastin 3
PPL periplakin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE4 ribonuclease, RNase A family, 4
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SH3YL1 SH3 and SYLF domain containing 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SVIL supervillin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TLR4 toll-like receptor 4