BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

339 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG1 adhesion G protein-coupled receptor G1
AMDHD2 amidohydrolase domain containing 2
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL2A1 BCL2-related protein A1
BDKRB2 bradykinin receptor B2
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
C5AR1 complement component 5a receptor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNL1 cyclin L1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSNK1E casein kinase 1, epsilon
CTSK cathepsin K
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMBP dynamin binding protein
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
FADS3 fatty acid desaturase 3
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLS glutaminase
GOLM1 golgi membrane protein 1
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IGL immunoglobulin lambda locus
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1R1 interleukin 1 receptor, type I
IL24 interleukin 24
IL4R interleukin 4 receptor
IL6 interleukin 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITM2B integral membrane protein 2B
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD1C jumonji domain containing 1C
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS8 lectin, galactoside-binding, soluble, 8
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LOX lysyl oxidase
LPL lipoprotein lipase
LRP10 low density lipoprotein receptor-related protein 10
LRRC15 leucine rich repeat containing 15
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM4 PDZ and LIM domain 4
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PXN paxillin
RAB38 RAB38, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS3 regulator of G-protein signaling 3
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RRAGD Ras-related GTP binding D
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC4 syndecan 4
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK3 SIK family kinase 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMOX spermine oxidase
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPAG9 sperm associated antigen 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SQRDL sulfide quinone reductase-like (yeast)
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
B3GNT1
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
C14ORF2 chromosome 14 open reading frame 2
C7 complement component 7
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK2 checkpoint kinase 2
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERLIN2 ER lipid raft associated 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FHL1 four and a half LIM domains 1
FYB FYN binding protein
GCLC glutamate-cysteine ligase, catalytic subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
LEPR leptin receptor
LSM1 LSM1, U6 small nuclear RNA associated
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
OLFML3 olfactomedin-like 3
PAK1IP1 PAK1 interacting protein 1
PCP4 Purkinje cell protein 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCB protein kinase C, beta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SRSF7 serine/arginine-rich splicing factor 7
SUB1 SUB1 homolog (S. cerevisiae)
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WWC1 WW and C2 domain containing 1