BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG1 B-cell translocation gene 1, anti-proliferative
CAPN2 calpain 2, (m/II) large subunit
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
COL7A1 collagen, type VII, alpha 1
CTSA cathepsin A
CTTN cortactin
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHCR7 7-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP3 epithelial membrane protein 3
FDPS farnesyl diphosphate synthase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
G0S2 G0/G1 switch 2
GPX4 glutathione peroxidase 4
GRN granulin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LRP10 low density lipoprotein receptor-related protein 10
LTBP1 latent transforming growth factor beta binding protein 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP1 matrix metallopeptidase 1
MVP major vault protein
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NUCB2 nucleobindin 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PRNP prion protein
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB31 RAB31, member RAS oncogene family
RAI14 retinoic acid induced 14
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
SYNJ2 synaptojanin 2
TANK TRAF family member-associated NFKB activator
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASCL1 achaete-scute family bHLH transcription factor 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C5 complement component 5
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDNRB endothelin receptor type B
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GPX3 glutathione peroxidase 3
GTSE1 G-2 and S-phase expressed 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MPHOSPH9 M-phase phosphoprotein 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
RRM2 ribonucleotide reductase M2
STRA13 stimulated by retinoic acid 13
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TTK TTK protein kinase
VAV3 vav 3 guanine nucleotide exchange factor