BRD-A15010982_10006350_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-A15010982_10006350_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CLDN3 claudin 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
COG7 component of oligomeric golgi complex 7
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EIF4A1 eukaryotic translation initiation factor 4A1
ELANE elastase, neutrophil expressed
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IL17RA interleukin 17 receptor A
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYZ lysozyme
MAP2K3 mitogen-activated protein kinase kinase 3
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MXI1 MAX interactor 1, dimerization protein
MYOF myoferlin
MZB1 marginal zone B and B1 cell-specific protein
NMRK1 nicotinamide riboside kinase 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PIEZO1 piezo-type mechanosensitive ion channel component 1
RAB25 RAB25, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX17 SRY (sex determining region Y)-box 17
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
STX4 syntaxin 4
SUSD4 sushi domain containing 4
SYNJ2 synaptojanin 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM30B transmembrane protein 30B
WIPI1 WD repeat domain, phosphoinositide interacting 1
WT1 Wilms tumor 1
ZNF394 zinc finger protein 394
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAA2 acetyl-CoA acyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRA3 adhesion G protein-coupled receptor A3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APLP2 amyloid beta (A4) precursor-like protein 2
ASCL1 achaete-scute family bHLH transcription factor 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIRC5 baculoviral IAP repeat containing 5
BTBD3 BTB (POZ) domain containing 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW1 basic leucine zipper and W2 domains 1
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CAPZB capping protein (actin filament) muscle Z-line, beta
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCNG2 cyclin G2
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP170 centrosomal protein 170kDa
CHEK2 checkpoint kinase 2
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COTL1 coactosin-like F-actin binding protein 1
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSC cathepsin C
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCLK1 doublecortin-like kinase 1
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
ELAVL1 ELAV like RNA binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ETV1 ets variant 1
EVL Enah/Vasp-like
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
FRZB frizzled-related protein
FSTL1 follistatin-like 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HDAC2 histone deacetylase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGB3 high mobility group box 3
HMGN1 high mobility group nucleosome binding domain 1
HMGN3 high mobility group nucleosomal binding domain 3
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPK heterogeneous nuclear ribonucleoprotein K
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
ITGB5 integrin, beta 5
KIF15 kinesin family member 15
LBR lamin B receptor
LDHB lactate dehydrogenase B
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MARCKSL1 MARCKS-like 1
MCM3 minichromosome maintenance complex component 3
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NAE1 NEDD8 activating enzyme E1 subunit 1
NAP1L1 nucleosome assembly protein 1-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
NES nestin
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCGF2 polycomb group ring finger 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGRMC1 progesterone receptor membrane component 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PTMA prothymosin, alpha
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCC1 regulator of chromosome condensation 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RUFY3 RUN and FYVE domain containing 3
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SEPT7 septin 7
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC35E2B solute carrier family 35, member E2B
SLIT2 slit homolog 2 (Drosophila)
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOBP sine oculis binding protein homolog (Drosophila)
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
SRSF1 serine/arginine-rich splicing factor 1
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN transgelin
TCAF1 TRPM8 channel-associated factor 1
TCF12 transcription factor 12
TCF3 transcription factor 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15B thymosin beta 15B
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TRIM2 tripartite motif containing 2
TRMT5 tRNA methyltransferase 5
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VRK1 vaccinia related kinase 1
WASF1 WAS protein family, member 1
WDR1 WD repeat domain 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPO1 exportin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF22 zinc finger protein 22