BRD-A15010982_10006350_NEU_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A15010982_10006350_NEU_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAPN2 calpain 2, (m/II) large subunit
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL15A1 collagen, type XV, alpha 1
COPA coatomer protein complex, subunit alpha
CREB3L1 cAMP responsive element binding protein 3-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP3 epithelial membrane protein 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FMO1 flavin containing monooxygenase 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
JMJD6 jumonji domain containing 6
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NANS N-acetylneuraminic acid synthase
OSER1 oxidative stress responsive serine-rich 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRGN serglycin
SRPR signal recognition particle receptor (docking protein)
STAR steroidogenic acute regulatory protein
STK10 serine/threonine kinase 10
TF transferrin
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BIK BCL2-interacting killer (apoptosis-inducing)
BTBD3 BTB (POZ) domain containing 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNA2 cyclin A2
CD24 CD24 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CEP68 centrosomal protein 68kDa
CLSTN1 calsyntenin 1
COLEC12 collectin sub-family member 12
CSNK1E casein kinase 1, epsilon
CTBP1 C-terminal binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAAM1 dishevelled associated activator of morphogenesis 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA3 EPH receptor A3
ETFB electron-transfer-flavoprotein, beta polypeptide
EYA1 EYA transcriptional coactivator and phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INSM1 insulinoma-associated 1
KIF2C kinesin family member 2C
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LPIN1 lipin 1
MARCKSL1 MARCKS-like 1
MEOX2 mesenchyme homeobox 2
MMD monocyte to macrophage differentiation-associated
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO10 myosin X
MYO5C myosin VC
MYO6 myosin VI
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NLGN4X neuroligin 4, X-linked
NREP neuronal regeneration related protein
NYNRIN NYN domain and retroviral integrase containing
OLFML3 olfactomedin-like 3
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTMA prothymosin, alpha
PTOV1 prostate tumor overexpressed 1
PXDN peroxidasin
RUFY3 RUN and FYVE domain containing 3
SALL2 spalt-like transcription factor 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
STK39 serine threonine kinase 39
STMN1 stathmin 1
TBC1D16 TBC1 domain family, member 16
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB15B thymosin beta 15B
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB3 tubulin, beta 3 class III
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VCAN versican
ZNF185 zinc finger protein 185 (LIM domain)
ZSCAN18 zinc finger and SCAN domain containing 18