BRD-A15010982_10006350_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A15010982_10006350_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
C1ORF106 chromosome 1 open reading frame 106
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COCH cochlin
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBA inhibin, beta A
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LRP10 low density lipoprotein receptor-related protein 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB1 tribbles pseudokinase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZYX zyxin

decreased expression

Symbol Name
CLU clusterin
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
OLFM1 olfactomedin 1
PDE4DIP phosphodiesterase 4D interacting protein
RPS27L ribosomal protein S27-like
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1