BRD-A15010982_10006350_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-A15010982_10006350_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4A ADP-ribosylation factor-like 4A
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BAG2 BCL2-associated athanogene 2
BOP1 block of proliferation 1
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CLDN8 claudin 8
CST6 cystatin E/M
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
HBEGF heparin-binding EGF-like growth factor
HOMER3 homer scaffolding protein 3
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB5 integrin, beta 5
LCN2 lipocalin 2
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LOC100286895 cell division cycle 27 homolog pseudogene
LTBP1 latent transforming growth factor beta binding protein 1
MFSD12 major facilitator superfamily domain containing 12
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
PAWR PRKC, apoptosis, WT1, regulator
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PLEK2 pleckstrin 2
PODXL podocalyxin-like
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SATB2 SATB homeobox 2
SCD5 stearoyl-CoA desaturase 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
WNT5B wingless-type MMTV integration site family, member 5B
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZYX zyxin

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARMCX6 armadillo repeat containing, X-linked 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BCL6 B-cell CLL/lymphoma 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CCNF cyclin F
CCNG1 cyclin G1
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHEK2 checkpoint kinase 2
CPNE3 copine III
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAPP E2F-associated phosphoprotein
EED embryonic ectoderm development
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXJ3 forkhead box J3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GSTA1 glutathione S-transferase alpha 1
HADH hydroxyacyl-CoA dehydrogenase
HILPDA hypoxia inducible lipid droplet-associated
HMGB2 high mobility group box 2
IGF1R insulin-like growth factor 1 receptor
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIAA0391 KIAA0391
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K6 mitogen-activated protein kinase kinase 6
MOAP1 modulator of apoptosis 1
MOB1A MOB kinase activator 1A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NBN nibrin
NET1 neuroepithelial cell transforming 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OLFML2A olfactomedin-like 2A
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PENK proenkephalin
PRKCD protein kinase C, delta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SPDEF SAM pointed domain containing ETS transcription factor
SRP54 signal recognition particle 54kDa
STAG2 stromal antigen 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TM2D3 TM2 domain containing 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM14A transmembrane protein 14A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TUBB tubulin, beta class I
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon