BRD-A14574269_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-A14574269_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLIC5 chloride intracellular channel 5
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
FGFR2 fibroblast growth factor receptor 2
FHOD3 formin homology 2 domain containing 3
FXYD6 FXYD domain containing ion transport regulator 6
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
HBEGF heparin-binding EGF-like growth factor
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IQGAP1 IQ motif containing GTPase activating protein 1
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
NDNF neuron-derived neurotrophic factor
OBSL1 obscurin-like 1
PCP4 Purkinje cell protein 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB21 RAB21, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
SELENBP1 selenium binding protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SOCS2 suppressor of cytokine signaling 2
SOX13 SRY (sex determining region Y)-box 13
SULF1 sulfatase 1
TCF21 transcription factor 21
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
CDKN2A cyclin-dependent kinase inhibitor 2A
CXCL5 chemokine (C-X-C motif) ligand 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
IGFBP6 insulin-like growth factor binding protein 6
ITGAV integrin, alpha V
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO2 LIM domain only 2 (rhombotin-like 1)
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUBB6 tubulin, beta 6 class V
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZMYM2 zinc finger, MYM-type 2