BRD-A14395271_MESORIDAZINE_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A14395271_MESORIDAZINE_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AEBP1 AE binding protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ASPN asporin
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD84 CD84 molecule
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
EDNRA endothelin receptor type A
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GCLC glutamate-cysteine ligase, catalytic subunit
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
KRT23 keratin 23, type I
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MXRA5 matrix-remodelling associated 5
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORC1 origin recognition complex, subunit 1
PAPD7 PAP associated domain containing 7
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTK2B protein tyrosine kinase 2 beta
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCAIP synuclein, alpha interacting protein
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YIPF6 Yip1 domain family, member 6
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AGTR1 angiotensin II receptor, type 1
ANXA6 annexin A6
APOD apolipoprotein D
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAG2 BCL2-associated athanogene 2
C16ORF45 chromosome 16 open reading frame 45
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COCH cochlin
CTSG cathepsin G
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR24 24-dehydrocholesterol reductase
EIF5A eukaryotic translation initiation factor 5A
GOLGA8A golgin A8 family, member A
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IL6ST interleukin 6 signal transducer
KIAA0368 KIAA0368
LEPR leptin receptor
MEGF9 multiple EGF-like-domains 9
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
NFIB nuclear factor I/B
NOTCH2 notch 2
OXTR oxytocin receptor
PRPF4 pre-mRNA processing factor 4
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP5 receptor accessory protein 5
RPS26 ribosomal protein S26
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SFN stratifin
STOM stomatin
STXBP1 syntaxin binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB18 zinc finger and BTB domain containing 18