BRD-A14178283_NP-004102_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A14178283_NP-004102_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CTBP2 C-terminal binding protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXL12 F-box and leucine-rich repeat protein 12
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MX1 MX dynamin-like GTPase 1
NEFL neurofilament, light polypeptide
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
THBS1 thrombospondin 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
VNN1 vanin 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AK1 adenylate kinase 1
ANXA6 annexin A6
APOA2 apolipoprotein A-II
ARMCX6 armadillo repeat containing, X-linked 6
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CCNB2 cyclin B2
CCNG1 cyclin G1
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CYBA cytochrome b-245, alpha polypeptide
DCXR dicarbonyl/L-xylulose reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DYNLT3 dynein, light chain, Tctex-type 3
ECI2 enoyl-CoA delta isomerase 2
EIF5A eukaryotic translation initiation factor 5A
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
GLB1 galactosidase, beta 1
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
HAUS4 HAUS augmin-like complex, subunit 4
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KIAA0101 KIAA0101
MAP2K6 mitogen-activated protein kinase kinase 6
MDK midkine (neurite growth-promoting factor 2)
MLEC malectin
MREG melanoregulin
OXA1L oxidase (cytochrome c) assembly 1-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PRDX6 peroxiredoxin 6
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTTG1 pituitary tumor-transforming 1
QPRT quinolinate phosphoribosyltransferase
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
TF transferrin
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TNNC1 troponin C type 1 (slow)
TSPAN3 tetraspanin 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)