BRD-A13946108_sulindac_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

163 genes differentially expressed following the BRD-A13946108_sulindac_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
ADCK3 aarF domain containing kinase 3
AGR2 anterior gradient 2
BAG2 BCL2-associated athanogene 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD59 CD59 molecule, complement regulatory protein
CHPT1 choline phosphotransferase 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FOXA2 forkhead box A2
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KLF5 Kruppel-like factor 5 (intestinal)
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MRPS16 mitochondrial ribosomal protein S16
MRPS30 mitochondrial ribosomal protein S30
NAMPT nicotinamide phosphoribosyltransferase
NRIP1 nuclear receptor interacting protein 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PI3 peptidase inhibitor 3, skin-derived
PITRM1 pitrilysin metallopeptidase 1
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLPI secretory leukocyte peptidase inhibitor
SOCS2 suppressor of cytokine signaling 2
SPP1 secreted phosphoprotein 1
STAT5B signal transducer and activator of transcription 5B
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN13 tetraspanin 13
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADGRL2 adhesion G protein-coupled receptor L2
ALOX15B arachidonate 15-lipoxygenase, type B
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOB apolipoprotein B
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP11B ATPase, class VI, type 11B
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
C14ORF132 chromosome 14 open reading frame 132
C3ORF14 chromosome 3 open reading frame 14
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH13 cadherin 13
CPE carboxypeptidase E
DEFB1 defensin, beta 1
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
EDN1 endothelin 1
EPAS1 endothelial PAS domain protein 1
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD6 frizzled class receptor 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HDAC9 histone deacetylase 9
HHEX hematopoietically expressed homeobox
HYOU1 hypoxia up-regulated 1
ICAM2 intercellular adhesion molecule 2
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISOC1 isochorismatase domain containing 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KLK5 kallikrein-related peptidase 5
LCN2 lipocalin 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LST1 leukocyte specific transcript 1
LYZ lysozyme
MAOB monoamine oxidase B
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
NID1 nidogen 1
NLRP2 NLR family, pyrin domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
PTPRC protein tyrosine phosphatase, receptor type, C
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN1 reticulon 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAP30 Sin3A-associated protein, 30kDa
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
SST somatostatin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TLE4 transducin-like enhancer of split 4
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395