BRD-A13188892_doxazosin_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

42 genes differentially expressed following the BRD-A13188892_doxazosin_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKAP12 A kinase (PRKA) anchor protein 12
CPA3 carboxypeptidase A3 (mast cell)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUOX2 dual oxidase 2
EPCAM epithelial cell adhesion molecule
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
MAGEB2 melanoma antigen family B2
NRGN neurogranin (protein kinase C substrate, RC3)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STAR steroidogenic acute regulatory protein
TFF3 trefoil factor 3 (intestinal)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ARHGAP29 Rho GTPase activating protein 29
BIRC5 baculoviral IAP repeat containing 5
CD44 CD44 molecule (Indian blood group)
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
IFITM1 interferon induced transmembrane protein 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KTN1 kinectin 1 (kinesin receptor)
LAMB3 laminin, beta 3
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP5 microfibrillar associated protein 5
MTDH metadherin
MTERF3 mitochondrial transcription termination factor 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
RABGGTB Rab geranylgeranyltransferase, beta subunit
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa