BRD-A13133631_FLUOROMETHOLONE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-A13133631_FLUOROMETHOLONE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM1 absent in melanoma 1
AREG amphiregulin
ASS1 argininosuccinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
CCND2 cyclin D2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLG5 discs, large homolog 5 (Drosophila)
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
FKBP1A FK506 binding protein 1A, 12kDa
FKBP5 FK506 binding protein 5
FLG filaggrin
FXYD2 FXYD domain containing ion transport regulator 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
HOPX HOP homeobox
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
LGALS2 lectin, galactoside-binding, soluble, 2
LRRC1 leucine rich repeat containing 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PI3 peptidase inhibitor 3, skin-derived
PRKCQ protein kinase C, theta
PRR15L proline rich 15-like
RBM3 RNA binding motif (RNP1, RRM) protein 3
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SGK1 serum/glucocorticoid regulated kinase 1
SI sucrase-isomaltase (alpha-glucosidase)
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TLR4 toll-like receptor 4
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CD58 CD58 molecule
COL14A1 collagen, type XIV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
EIF5A eukaryotic translation initiation factor 5A
ERAP2 endoplasmic reticulum aminopeptidase 2
FADS1 fatty acid desaturase 1
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
MARCKS myristoylated alanine-rich protein kinase C substrate
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
NGRN neugrin, neurite outgrowth associated
NKX3-1 NK3 homeobox 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
PLAU plasminogen activator, urokinase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTHLH parathyroid hormone-like hormone
QKI QKI, KH domain containing, RNA binding
RBP4 retinol binding protein 4, plasma
SC5D sterol-C5-desaturase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF11 serine/arginine-rich splicing factor 11
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRA2A transformer 2 alpha homolog (Drosophila)
TXNDC9 thioredoxin domain containing 9