BRD-A13122391_16-HYDROXYTRIPTOLIDE_VCAP_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_VCAP_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABLIM1 actin binding LIM protein 1
AEBP1 AE binding protein 1
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ATP10D ATPase, class V, type 10D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
C1ORF54 chromosome 1 open reading frame 54
CD24 CD24 molecule
CD93 CD93 molecule
CFB complement factor B
CHRDL1 chordin-like 1
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
CNPY3 canopy FGF signaling regulator 3
CP ceruloplasmin (ferroxidase)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGFR3 fibroblast growth factor receptor 3
FXYD5 FXYD domain containing ion transport regulator 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2C integral membrane protein 2C
KDM5D lysine (K)-specific demethylase 5D
MECOM MDS1 and EVI1 complex locus
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC16 mucin 16, cell surface associated
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSENEN presenilin enhancer gamma secretase subunit
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP1 retinol binding protein 1, cellular
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SORBS1 sorbin and SH3 domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
STAB1 stabilin 1
TKTL1 transketolase-like 1
TMEM176B transmembrane protein 176B
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMD1 adenosylmethionine decarboxylase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BCL2A1 BCL2-related protein A1
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EXOSC4 exosome component 4
FAM46C family with sequence similarity 46, member C
GATA2 GATA binding protein 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
JMJD6 jumonji domain containing 6
KLF2 Kruppel-like factor 2
LDLR low density lipoprotein receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MMP9 matrix metallopeptidase 9
MSL2 male-specific lethal 2 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RAP2B RAP2B, member of RAS oncogene family
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX4 SRY (sex determining region Y)-box 4
TBC1D4 TBC1 domain family, member 4
TBX3 T-box 3
TGFBR3 transforming growth factor, beta receptor III
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAF4 TNF receptor-associated factor 4
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VLDLR very low density lipoprotein receptor
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZBTB10 zinc finger and BTB domain containing 10