BRD-A13122391_16-HYDROXYTRIPTOLIDE_T3M10_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_T3M10_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ADAMDEC1 ADAM-like, decysin 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL3 ADP-ribosylation factor-like 3
BSG basigin (Ok blood group)
CD59 CD59 molecule, complement regulatory protein
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTSS cathepsin S
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR4 fibroblast growth factor receptor 4
FZD6 frizzled class receptor 6
GLG1 golgi glycoprotein 1
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KLHL21 kelch-like family member 21
LUM lumican
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MNAT1 MNAT CDK-activating kinase assembly factor 1
MX1 MX dynamin-like GTPase 1
NOSIP nitric oxide synthase interacting protein
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRL platelet-derived growth factor receptor-like
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RER1 retention in endoplasmic reticulum sorting receptor 1
RSAD2 radical S-adenosyl methionine domain containing 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SNX10 sorting nexin 10
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
THY1 Thy-1 cell surface antigen
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN4 tetraspanin 4
TUSC3 tumor suppressor candidate 3
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AREG amphiregulin
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BCOR BCL6 corepressor
BEX1 brain expressed, X-linked 1
CD83 CD83 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EREG epiregulin
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MID1IP1 MID1 interacting protein 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSL2 male-specific lethal 2 homolog (Drosophila)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PTX3 pentraxin 3, long
PURA purine-rich element binding protein A
RGS2 regulator of G-protein signaling 2
RHOG ras homolog family member G
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
ZFP36L2 ZFP36 ring finger protein-like 2