BRD-A13122391_16-HYDROXYTRIPTOLIDE_SW948_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_SW948_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AIM1 absent in melanoma 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ARG2 arginase 2
ASPN asporin
C3ORF14 chromosome 3 open reading frame 14
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DGKA diacylglycerol kinase, alpha 80kDa
ECM1 extracellular matrix protein 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
GPM6A glycoprotein M6A
GSE1 Gse1 coiled-coil protein
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KIAA1462 KIAA1462
LEF1 lymphoid enhancer-binding factor 1
MMP11 matrix metallopeptidase 11
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
NMRK1 nicotinamide riboside kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
NTAN1 N-terminal asparagine amidase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM3 PDZ and LIM domain 3
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROSC proline synthetase co-transcribed homolog (bacterial)
PYCARD PYD and CARD domain containing
RPS4Y1 ribosomal protein S4, Y-linked 1
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TP53TG1 TP53 target 1 (non-protein coding)
TSPAN7 tetraspanin 7
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRA2A adrenoceptor alpha 2A
AMOTL2 angiomotin like 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
CCL2 chemokine (C-C motif) ligand 2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ENDOD1 endonuclease domain containing 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB14 growth factor receptor-bound protein 14
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
LAMB3 laminin, beta 3
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MEGF9 multiple EGF-like-domains 9
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PROM1 prominin 1
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM25 RNA binding motif protein 25
RIN2 Ras and Rab interactor 2
RPL27A ribosomal protein L27a
RPL36 ribosomal protein L36
S100A6 S100 calcium binding protein A6
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TXLNA taxilin alpha
XBP1 X-box binding protein 1