BRD-A13122391_16-HYDROXYTRIPTOLIDE_SW620_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_SW620_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANKRD10 ankyrin repeat domain 10
ANXA5 annexin A5
APOD apolipoprotein D
ATMIN ATM interactor
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCL13 chemokine (C-C motif) ligand 13
CD24 CD24 molecule
CKM creatine kinase, muscle
CNN1 calponin 1, basic, smooth muscle
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
COX6C cytochrome c oxidase subunit VIc
CPT1A carnitine palmitoyltransferase 1A (liver)
CSRP2 cysteine and glycine-rich protein 2
CST6 cystatin E/M
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DSP desmoplakin
EDNRA endothelin receptor type A
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FUCA1 fucosidase, alpha-L- 1, tissue
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GHITM growth hormone inducible transmembrane protein
GLS glutaminase
GOLGA8B golgin A8 family, member B
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HOXC10 homeobox C10
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IL2RG interleukin 2 receptor, gamma
KCTD5 potassium channel tetramerization domain containing 5
LAMP3 lysosomal-associated membrane protein 3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MLF1 myeloid leukemia factor 1
MYBPC1 myosin binding protein C, slow type
NAP1L3 nucleosome assembly protein 1-like 3
NEB nebulin
NID2 nidogen 2 (osteonidogen)
NISCH nischarin
NPY neuropeptide Y
NQO2 NAD(P)H dehydrogenase, quinone 2
NT5E 5'-nucleotidase, ecto (CD73)
OXCT1 3-oxoacid CoA transferase 1
PALLD palladin, cytoskeletal associated protein
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A13 S100 calcium binding protein A13
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGR SH3 domain binding glutamate-rich protein
SLC22A18 solute carrier family 22, member 18
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOAT1 sterol O-acyltransferase 1
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNM synemin, intermediate filament protein
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCAF1 TRPM8 channel-associated factor 1
THBS2 thrombospondin 2
TPM2 tropomyosin 2 (beta)
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
UBE3B ubiquitin protein ligase E3B
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AMOTL2 angiomotin like 2
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COPS7A COP9 signalosome subunit 7A
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FBL fibrillarin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
HAL histidine ammonia-lyase
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JMJD6 jumonji domain containing 6
KAZN kazrin, periplakin interacting protein
KLHL9 kelch-like family member 9
KRT23 keratin 23, type I
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
METTL7A methyltransferase like 7A
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NXT1 nuclear transport factor 2-like export factor 1
ORM1 orosomucoid 1
PCGF1 polycomb group ring finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PTX3 pentraxin 3, long
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RPL31 ribosomal protein L31
RPL37A ribosomal protein L37a
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMNDC1 survival motor neuron domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFBI transforming growth factor, beta-induced, 68kDa
TNS3 tensin 3
TRD T cell receptor delta locus
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UCK2 uridine-cytidine kinase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF410 zinc finger protein 410