BRD-A13122391_16-HYDROXYTRIPTOLIDE_PL21_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_PL21_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM28 ADAM metallopeptidase domain 28
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
AMT aminomethyltransferase
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
BZW2 basic leucine zipper and W2 domains 2
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLEC2B C-type lectin domain family 2, member B
CRYL1 crystallin, lambda 1
CSRP2 cysteine and glycine-rich protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND1B DENN/MADD domain containing 1B
DES desmin
DMPK dystrophia myotonica-protein kinase
EDNRA endothelin receptor type A
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
INSM1 insulinoma-associated 1
KIAA0226L KIAA0226-like
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LGMN legumain
MDK midkine (neurite growth-promoting factor 2)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL1 MICAL-like 1
MYH11 myosin, heavy chain 11, smooth muscle
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OXCT1 3-oxoacid CoA transferase 1
PBLD phenazine biosynthesis-like protein domain containing
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDLIM1 PDZ and LIM domain 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RAB31 RAB31, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SMTN smoothelin
SORBS1 sorbin and SH3 domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAB1 stabilin 1
TKTL1 transketolase-like 1
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADRB2 adrenoceptor beta 2, surface
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDNF brain-derived neurotrophic factor
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUOX2 dual oxidase 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
FADD Fas (TNFRSF6)-associated via death domain
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FZD2 frizzled class receptor 2
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HK2 hexokinase 2
HMG20B high mobility group 20B
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAPK6 mitogen-activated protein kinase 6
MAX MYC associated factor X
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MID1IP1 MID1 interacting protein 1
MNDA myeloid cell nuclear differentiation antigen
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP62 nucleoporin 62kDa
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRKCD protein kinase C, delta
PRPF4B pre-mRNA processing factor 4B
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PXDN peroxidasin
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS4 regulator of G-protein signaling 4
RIN2 Ras and Rab interactor 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SESN1 sestrin 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAK2 trafficking protein, kinesin binding 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1